Kornelia polyak biography of christopher
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Endometrial, lung, and survivorship studies headline Dana-Farber research at AACR Annual Meeting
Numerous studies conducted by researchers at Dana-Farber Cancer Institute show promising results for patients with endometrial, lung, breast, prostate, and colorectal cancers. The results of these studies, along with dozens of others led by Dana-Farber faculty, will be presented at this year's American Association for Cancer Research (AACR) Annual Meeting on April , , in San Diego, Calif.
The institute's leading experts and researchers will present findings across a spectrum of diseases, underscoring their dedication to driving innovation, improving patient outcomes, and changing lives everywhere.
Rebecca Porter, MD, PhD, a medical oncologist in the Gynecological Oncology Program of the Susan F. Smith Center for Women's Cancers, will present "A phase 2, two-stage study of mirvetuximab soravtansine (IMGN) in combination with pembrolizumab in patients with microsatellite stable (MSS)
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Cancer genomics just got personal
- Editorial
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Genome Biologyvolume 15, Article number: () Cite this article
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It was one Saturday morning in April when, after a hour journey across half of the world, and a very early morning start to the AACR annual meeting marathon, I was sitting in a dark room in the San Diego Convention Center listening to Kornelia Polyak's talk about the evolution of breast cancer. Polyak, an expert in breast cancer genomics, was reporting on some recent results from her group. Then, she made a statement that for many cancer researchers will perhaps seem obvious, but that was not yet obvious to me. Polyak noted that it is not uncommon that when several different clones of cancer are present in a patient, the clone that metastasizes is not the most aggressive one.
This does of course make a lot of sense: the clone that metastasizes doesn't need to be aggressive at all. Rathe
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Early-Life Body Adiposity and the Breast Tumor Transcriptome
Background: Cumulative epidemiologic bevis has shown that early-life adiposity fryst vatten strongly inversely associated with breast cancer risk throughout life, independent of adult obesity. However, the molecular mechanisms remain poorly understood.
Methods: We assessed the association of early-life adiposity, defined as self-reported body size during ages years from a validated 9-level pictogram, with the transcriptome of breast tumor (N = ) and tumor-adjacent histologically normal tissue (N = ) in the Nurses' Health Study. We conducted multivariable linear regression analysis to identify differentially expressed genes in tumor and tumor-adjacent tissue, respectively. Molecular pathway analysis using Hallmark gene sets (N = 50) was further performed to gain biological insights. Analysis was stratified by tumor estrogen receptor (ER) protein expression ställning eller tillstånd (n = for ER+ and for ER- tumors).
Results: No gen