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- Mental health status of people isolated due to Middle East Respiratory Syndrome
- Hyunsuk Jeong, Hyeon Woo Yim, Yeong-Jun Song, Moran Ki, Jung-Ah Min, Juhee Cho, Jeong-Ho Chae
- Epidemiol Health. ;e Published online November 5,
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Abstract
OBJECTIVES
Isolation due to the management of infectious diseases is thought to affect mental health, but the effects are still unknown. We examined the prevalence of anxiety symptoms and anger in persons isolated during the Middle East Respiratory Syndrome (MERS) epidemic both at isolation period and at four to six months after release from isolation. We also determined risk factors associated with these symptoms at four to six months.METHODS
Of 14, individuals isolated for 2-week due to having contact with MERS patients in , when MERS was introduced to Korea, 1, individuals were i•
. Author manuscript; available in PMC: MayPublished in final edited form as: Diabetes. Feb 11;65(5)– doi: /db
Abstract
Insulin resistance in mice typically does not manifest as diabetes due to multiple compensatory mechanisms. Here we present a novel digenic model of type 2 diabetes in mice heterozygous for a null allele of the Insulin Receptor and an N-ethyl-N- nitrosourea induced alternative splice mutation in the regulatory protein phosphatase 2A (PP2A) subunit PPP2R2A. Inheritance of either allele independently results in insulin resistance but not overt diabetes. Doubly heterozygous mice exhibit progressive hyperglycaemia, hyperinsulinaemia and impaired glucose tolerance from 12 weeks of age without significant increase in bodyweight. Alternative splicing of Ppp2r2a decreased PPP2R2A protein levels. This reduction in PPP2R2A containing PP2A phosphatase holoenzyme was associated with decreased serine/threonine protein kinase AKT protein levels. Ultimately, reduced i
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Joys or Sorrows of Parenting During the COVID Lockdown: A Scoping Review
Introduction
The management of the early phases of the COVID pandemic has involved aggressive mitigation measures, including stay-at-home restrictions and strict physical distancing, school and workplace closures, a temporary, complete lockdown of businesses, and cancellation of public events, all geared towards reducing the spread and impact of infections [14]. The World Health Organization recommends that countries update their pandemic preparedness plans based on lessons learnt from previous outbreaks and latest evidence available on the effectiveness of containment and mitigation measures [5]. However, while evidence is growing on their effectiveness, less is known on the impact of such measures [611]. Most studies to date have focused on the impact of mitigation measures, particularly lockdown measures, on older adults [1216] and children and adolescents [1724].
Other populations were af